Making Flavone Thioethers Using Halides and Powdered Sulfur or Na2S2O3

The method for constructing C–S bonds is very important in organic synthesis. Here a new sulfenylation method to generate flavone thioether derivatives was developed by employing aromatic or alkyl halides, S powder and Na2S2O3 as reactants. Good yields of regioselective Calkyl–S and Caryl–S-substitu...

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Veröffentlicht in:Journal of organic chemistry 2017-10, Vol.82 (19), p.10617-10622
Hauptverfasser: Tang, Qiujie, Bian, Zhaogang, Wu, Wei, Wang, Jin, Xie, Ping, Pittman, Charles U, Zhou, Aihua
Format: Artikel
Sprache:eng
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Zusammenfassung:The method for constructing C–S bonds is very important in organic synthesis. Here a new sulfenylation method to generate flavone thioether derivatives was developed by employing aromatic or alkyl halides, S powder and Na2S2O3 as reactants. Good yields of regioselective Calkyl–S and Caryl–S-substituted flavones were generated under relatively environmentally friendly and simple conditions. This method might be potentially applicable to large scale production, and it enriches current sulfenylation methods.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b01320