Tumour infiltrating lymphocytes are predictors of lymph node metastasis in early gastric cancers

Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Cli...

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Veröffentlicht in:	Pathology 2017-10, Vol.49 (6), p.589-595
Hauptverfasser:	Kim, Joo Young, Kim, Chul Hwan, Lee, Youngseok, Lee, Jeong Hyeon, Chae, Yang-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Crohn's-like lymphoid reaction Early Detection of Cancer Early gastric cancers Female FOXA1 Hepatocyte Nuclear Factor 3-alpha - metabolism Humans lymph node metastasis Lymph Nodes - pathology Lymphatic Metastasis Lymphocytes, Tumor-Infiltrating - pathology Male Middle Aged Multivariate Analysis Prognosis Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tumor Microenvironment tumour stromal percentage tumour-infiltrating lymphocytes
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Zusammenfassung:	Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Clinicopathological variables and tumour-infiltrating lymphocytes (TILs), Crohn's-like lymphoid reaction (CLR), tumour stromal percentage (TSP), and FOXA1 expression were evaluated and correlated with LNM. Among the 102 cases, 68 cases (66.7%) had low TILs and 34 cases (33.3%) had high TILs. High TILs were significantly correlated with the absence of LNM (p
ISSN:	0031-3025 1465-3931
DOI:	10.1016/j.pathol.2017.06.003