Synthesis and biological evaluation of C-12′ substituted vinflunine derivatives

A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines. A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.18 (16), p.4602-4605
Hauptverfasser:	Sheng, Lei Xin, Da, Yu Xiang, Long, Yin, Hong, Liu Zhen, Cho, Tang Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 cell lines Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Design Drug Screening Assays, Antitumor General aspects Humans In vitro Inhibitory Concentration 50 Medical sciences Microtubules - chemistry Models, Chemical Molecular Conformation Pharmacology. Drug treatments Sodium Azide - pharmacology Synthesized Tubulin - chemistry Vinblastine - analogs & derivatives Vinblastine - chemical synthesis Vinblastine - chemistry Vinblastine - pharmacology Vinflunine derivatives
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Zusammenfassung:	A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines. A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.07.025