A comparative study on the raft chemical properties of various alginate antacid raft-forming products

Objective: Research to measure the chemical characterization of alginate rafts for good raft performance and ascertain how formulation can affect chemical parameters. Significance: A selection of alginate formulations was investigated all claiming to be proficient raft formers with significance between products established and ranked. Methods: Procedures were selected which demonstrated the chemical characterization allowing rafts to effectively impede the reflux into the esophagus or in severe cases to be refluxed preferentially into the esophagus and exert a demulcent effect, with focus of current research on methods which complement previous studies centered on physical properties. The alginate content was analyzed by a newly developed HPLC method. Methods were used to determine the neutralization profile and the acid neutralization within the raft determined along with how raft structure affects neutralization. Results: Alginate content of Gaviscon Double Action (GDA) within the raft was significantly superior (p