Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach

The objective of this study was to evaluate the antioxidant effects of propolis, caffeic acid phenethyl ester (CAPE; active compound in propolis), and pollen on biochemical oxidative stress biomarkers in rat kidney tissue inhibited by Nω‐nitro‐L‐arginine methyl ester (L‐NAME). The biomarkers evaluat...

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Veröffentlicht in:	Cell biochemistry and function 2017-08, Vol.35 (6), p.304-314
Hauptverfasser:	Salmas, Ramin Ekhteiari, Gulhan, Mehmet Fuat, Durdagi, Serdar, Sahna, Engin, Abdullah, Huda I., Selamoglu, Zeliha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Arginine Arginine - analogs & derivatives Arginine - metabolism Arginine - toxicity Aryldialkylphosphatase - metabolism Binding energy Binding Sites Biomarkers Caffeic acid Caffeic Acids - chemistry Caffeic Acids - metabolism Caffeic Acids - pharmacology CAPE Catalysis Glutathione Glutathione reductase Glutathione Reductase - chemistry Glutathione Reductase - metabolism Half-Life Hypertension Hypertension - metabolism Hypertension - pathology Kidney Diseases - etiology Kidney Diseases - metabolism Kidneys Male MM‐PBSA Molecular Docking Simulation Molecular Dynamics Simulation molecular dynamics simulations molecular modeling Molecular modelling NF-kappa B - metabolism NF-κB protein NG-Nitroarginine methyl ester Oxidative stress Oxidative Stress - drug effects Paraoxonase Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - chemistry Phenylethyl Alcohol - metabolism Phenylethyl Alcohol - pharmacology Pollen Pollen - chemistry Pollen - metabolism Propolis Propolis - metabolism Propolis - pharmacology Protein Structure, Tertiary Rats Rats, Sprague-Dawley Rodents Thermodynamics
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Zusammenfassung:	The objective of this study was to evaluate the antioxidant effects of propolis, caffeic acid phenethyl ester (CAPE; active compound in propolis), and pollen on biochemical oxidative stress biomarkers in rat kidney tissue inhibited by Nω‐nitro‐L‐arginine methyl ester (L‐NAME). The biomarkers evaluated were paraoxonase (PON1), oxidative stress index (OSI), total antioxidant status (TAS), total oxidant status (TOS), asymmetric dimethylarginine (ADMA), and nuclear factor kappa B (NF‐κB). TAS levels and PON1 activity were significantly decreased in kidney tissue samples in the L‐NAME‐treated group (P
ISSN:	0263-6484 1099-0844
DOI:	10.1002/cbf.3277