Steroid-resistant erythroderma and alopecia in a newborn

[1],[2],[3] Although genetic studies identified the responsible gene for this condition on chromosome 5q32, named serine protease inhibitor Kazal-type 5, which is responsible for encoding an inhibitor of serine proteases called lymphoepithelial Kazal-type-related inhibitor, genetic testing is not required yet to confirm the diagnosis.[4] The differential diagnosis of an erythemato-squamous rash in infants includes physiologic scaling and redness, psoriasis, seborrheic or atopic dermatitis, scabies, immunodeficiency, ectodermal dysplasias, acrodermatitis enteropathica and Netherton syndrome.[5] It is caused by various infections and food allergies (cow milk, egg white, peanuts, wheat and fish).