Amyloid in Alzheimer’s Disease: Guilty Beyond Reasonable Doubt?

Amyloid in Alzheimer’s Disease: Guilty Beyond Reasonable Doubt?

Recently failed antiamyloidogenic trials call for an objective reassessment of the dominating amyloid cascade hypothesis of Alzheimer’s disease (AD). Ongoing efforts focusing on amyloid β protein (Aβ), its deposition, and its removal need to be complemented by more intensive research in new directio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2017-10, Vol.38 (10), p.849-851
1. Verfasser: Behl, Christian
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Amyloid - metabolism
Animals
Humans
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Recently failed antiamyloidogenic trials call for an objective reassessment of the dominating amyloid cascade hypothesis of Alzheimer’s disease (AD). Ongoing efforts focusing on amyloid β protein (Aβ), its deposition, and its removal need to be complemented by more intensive research in new directions. Those may either integrate amyloid pathology or will propose pathogenetic routes independent of Aβ in the search for the causes of AD.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2017.07.002