Prognostic value of lymph node-to-primary tumor standardized uptake value ratio in endometrioid endometrial carcinoma

Purpose To determine whether the relative metabolic activity of pelvic or para-aortic LN compared with that of primary tumor measured by preoperative [ 18 F]FDG PET/CT scan has prognostic value in patients with endometrioid endometrial carcinoma. Methods We retrospectively reviewed patients with end...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2018, Vol.45 (1), p.47-55
Hauptverfasser:	Chung, Hyun Hoon, Cheon, Gi Jeong, Kim, Jae-Weon, Park, Noh-Hyun, Song, Yong Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aorta Carcinoma Carcinoma - diagnostic imaging Carcinoma - pathology Cardiology Computed tomography Endometrial cancer Endometrial Neoplasms - diagnostic imaging Endometrial Neoplasms - pathology Endometrium Female Fluorodeoxyglucose F18 Gynecology Humans Imaging Lymph nodes Lymph Nodes - diagnostic imaging Medicine Medicine & Public Health Metabolism Metastases Middle Aged Myometrium Neoplasm Recurrence, Local - diagnostic imaging Nuclear Medicine Obstetrics Oncology Original Article Orthopedics Patients Positron emission Positron Emission Tomography Computed Tomography - methods Positron Emission Tomography Computed Tomography - standards Predictive Value of Tests Quality Radiology Radiopharmaceuticals Regression analysis Risk analysis Risk factors Tomography Uterine cancer
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Zusammenfassung:	Purpose To determine whether the relative metabolic activity of pelvic or para-aortic LN compared with that of primary tumor measured by preoperative [ 18 F]FDG PET/CT scan has prognostic value in patients with endometrioid endometrial carcinoma. Methods We retrospectively reviewed patients with endometrioid endometrial carcinoma who underwent preoperative [ 18 F]FDG PET/CT scans. Prognostic values of PET/CT-derived metabolic variables such as maximum standardized uptake value (SUV) of the primary endometrial carcinoma (SUV Tumor ) and LN (SUV LN ), and the LN-to-endometrial carcinoma SUV ratio (SUV LN / SUV Tumor ) were assessed. Results Clinico-pathological data, imaging data, and treatment results were reviewed for 107 eligible patients. Median post-surgical follow-up was 23 months (range, 6–60), and 7 (6.5%) patients experienced recurrence. Regression analysis showed that SUV LN / SUV Tumor ( P
ISSN:	1619-7070 1619-7089
DOI:	10.1007/s00259-017-3805-2