CuCl/Et3N‑Catalyzed Synthesis of Indanone-Fused 2‑Methylene Pyrrolidines from Enynals and Propargylamines
An efficient CuCl/Et3N-catalyzed tandem reaction for the synthesis of indanone-fused pyrrolidine was developed. In this process, two rings and four bonds are generated in one pot with high atom-economy and step-efficiency. The addition of Et3N was found as the key factor for the success of the tande...
Gespeichert in:
| Veröffentlicht in: | Organic letters 2017-09, Vol.19 (17), p.4540-4543 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | An efficient CuCl/Et3N-catalyzed tandem reaction for the synthesis of indanone-fused pyrrolidine was developed. In this process, two rings and four bonds are generated in one pot with high atom-economy and step-efficiency. The addition of Et3N was found as the key factor for the success of the tandem reaction. |
|---|---|
| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/acs.orglett.7b02121 |