Case–control study of chronic low‐level exposure of inorganic arsenic species and non‐melanoma skin cancer
A significant relationship between arsenic exposure and non‐melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitati...
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| Veröffentlicht in: | Journal of dermatology 2017-12, Vol.44 (12), p.1374-1379 |
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| creator | Kim, Tae‐Hoon Seo, Jeong‐Wook Hong, Young‐Seoub Song, Ki‐Hoon |
| description | A significant relationship between arsenic exposure and non‐melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitative exposure assessment of arsenic species in NMSC patients. To validate the contribution of each arsenic species to NMSC, we compared the creatinine‐adjusted urinary concentration of arsenic species in NMSC patients and community controls. A total of 124 biopsy‐proven NMSC cases and 125 age‐ and sex‐matched community controls, drinking tap water with low‐level arsenic concentration ( |
| doi_str_mv | 10.1111/1346-8138.13993 |
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The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitative exposure assessment of arsenic species in NMSC patients. To validate the contribution of each arsenic species to NMSC, we compared the creatinine‐adjusted urinary concentration of arsenic species in NMSC patients and community controls. A total of 124 biopsy‐proven NMSC cases and 125 age‐ and sex‐matched community controls, drinking tap water with low‐level arsenic concentration (<5 μg/L), were included in the study. High‐performance liquid chromatography and inductively coupled plasma mass spectrometry were used for the measurement. The NMSC group was found to have significantly higher levels of total inorganic arsenic, trivalent and pentavalent arsenic and monomethylarsonic acid than the control group. Total arsenic, organic arsenic and dimethylarsonic acid levels were lower in the NMSC group. We suggest that inorganic arsenic species, trivalent arsenic and pentavalent arsenic may influence the prevalence of NMSC, in spite of these levels being lower than the Agency for Toxic Substances and Disease Registry‐recommended standard or the levels reported by other highly contaminated areas and neighboring countries in East Asia. Furthermore, it also suggests that total arsenic level cannot represent the risk of NMSC.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.13993</identifier><identifier>PMID: 28815697</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Arsenic ; Arsenic - toxicity ; Arsenicals - urine ; basal cell carcinoma ; Biopsy ; Case-Control Studies ; Creatinine ; Female ; High-performance liquid chromatography ; Humans ; Male ; Mass spectroscopy ; Melanoma ; Middle Aged ; non‐melanoma skin cancer ; Risk assessment ; Skin cancer ; Skin Neoplasms - chemically induced ; speciation ; Species ; squamous cell carcinoma ; Toxicity</subject><ispartof>Journal of dermatology, 2017-12, Vol.44 (12), p.1374-1379</ispartof><rights>2017 Japanese Dermatological Association</rights><rights>2017 Japanese Dermatological Association.</rights><rights>Copyright © 2017 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3953-1edb6f8dd72abefe633d72b306b6af781af72741898fbbc8fdb5b7796cbf23153</citedby><cites>FETCH-LOGICAL-c3953-1edb6f8dd72abefe633d72b306b6af781af72741898fbbc8fdb5b7796cbf23153</cites><orcidid>0000-0003-1429-8779</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.13993$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.13993$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28815697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Tae‐Hoon</creatorcontrib><creatorcontrib>Seo, Jeong‐Wook</creatorcontrib><creatorcontrib>Hong, Young‐Seoub</creatorcontrib><creatorcontrib>Song, Ki‐Hoon</creatorcontrib><title>Case–control study of chronic low‐level exposure of inorganic arsenic species and non‐melanoma skin cancer</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>A significant relationship between arsenic exposure and non‐melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitative exposure assessment of arsenic species in NMSC patients. To validate the contribution of each arsenic species to NMSC, we compared the creatinine‐adjusted urinary concentration of arsenic species in NMSC patients and community controls. A total of 124 biopsy‐proven NMSC cases and 125 age‐ and sex‐matched community controls, drinking tap water with low‐level arsenic concentration (<5 μg/L), were included in the study. High‐performance liquid chromatography and inductively coupled plasma mass spectrometry were used for the measurement. The NMSC group was found to have significantly higher levels of total inorganic arsenic, trivalent and pentavalent arsenic and monomethylarsonic acid than the control group. Total arsenic, organic arsenic and dimethylarsonic acid levels were lower in the NMSC group. We suggest that inorganic arsenic species, trivalent arsenic and pentavalent arsenic may influence the prevalence of NMSC, in spite of these levels being lower than the Agency for Toxic Substances and Disease Registry‐recommended standard or the levels reported by other highly contaminated areas and neighboring countries in East Asia. Furthermore, it also suggests that total arsenic level cannot represent the risk of NMSC.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arsenic</subject><subject>Arsenic - toxicity</subject><subject>Arsenicals - urine</subject><subject>basal cell carcinoma</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Creatinine</subject><subject>Female</subject><subject>High-performance liquid chromatography</subject><subject>Humans</subject><subject>Male</subject><subject>Mass spectroscopy</subject><subject>Melanoma</subject><subject>Middle Aged</subject><subject>non‐melanoma skin cancer</subject><subject>Risk assessment</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - chemically induced</subject><subject>speciation</subject><subject>Species</subject><subject>squamous cell carcinoma</subject><subject>Toxicity</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbFOHDEQhq0IFA6Smi6yREOzd_b6dm2X6CBAhJQmqS3bO04Wdu2NfQtcxyNE4g15ErwcoaCJi5nR-Jtfo38QOqRkTvNbULasC0GZmFMmJfuAZm-dHTQjTFRFuSR8D-2ndE1IKStKPqK9Ugha1ZLP0LDSCZ4eHm3w6xg6nNZjs8HBYfs7Bt9a3IW7p4e_HdxCh-F-CGmMMP23PsRfeiJ0TDDlNIBtIWHtG-yDz1M9dNqHXuN003pstbcQP6Fdp7sEn1_zAfr59ezH6qK4-n5-uTq5KiyTFSsoNKZ2oml4qQ04qBnLpWGkNrV2XNAcSr6kQgpnjBWuMZXhXNbWuJLRih2g463uEMOfEdJa9W2y0OWNIIxJUcnIUmTZOqNH79DrMEaft8sUL6ksmeSZWmwpG0NKEZwaYtvruFGUqOkYarJeTdarl2PkiS-vuqPpoXnj_7mfgWoL3LUdbP6np76dnm2FnwEZUJgk</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Kim, Tae‐Hoon</creator><creator>Seo, Jeong‐Wook</creator><creator>Hong, Young‐Seoub</creator><creator>Song, Ki‐Hoon</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1429-8779</orcidid></search><sort><creationdate>201712</creationdate><title>Case–control study of chronic low‐level exposure of inorganic arsenic species and non‐melanoma skin cancer</title><author>Kim, Tae‐Hoon ; Seo, Jeong‐Wook ; Hong, Young‐Seoub ; Song, Ki‐Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3953-1edb6f8dd72abefe633d72b306b6af781af72741898fbbc8fdb5b7796cbf23153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arsenic</topic><topic>Arsenic - toxicity</topic><topic>Arsenicals - urine</topic><topic>basal cell carcinoma</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Creatinine</topic><topic>Female</topic><topic>High-performance liquid chromatography</topic><topic>Humans</topic><topic>Male</topic><topic>Mass spectroscopy</topic><topic>Melanoma</topic><topic>Middle Aged</topic><topic>non‐melanoma skin cancer</topic><topic>Risk assessment</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - chemically induced</topic><topic>speciation</topic><topic>Species</topic><topic>squamous cell carcinoma</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Tae‐Hoon</creatorcontrib><creatorcontrib>Seo, Jeong‐Wook</creatorcontrib><creatorcontrib>Hong, Young‐Seoub</creatorcontrib><creatorcontrib>Song, Ki‐Hoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Tae‐Hoon</au><au>Seo, Jeong‐Wook</au><au>Hong, Young‐Seoub</au><au>Song, Ki‐Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case–control study of chronic low‐level exposure of inorganic arsenic species and non‐melanoma skin cancer</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>44</volume><issue>12</issue><spage>1374</spage><epage>1379</epage><pages>1374-1379</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>A significant relationship between arsenic exposure and non‐melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitative exposure assessment of arsenic species in NMSC patients. To validate the contribution of each arsenic species to NMSC, we compared the creatinine‐adjusted urinary concentration of arsenic species in NMSC patients and community controls. A total of 124 biopsy‐proven NMSC cases and 125 age‐ and sex‐matched community controls, drinking tap water with low‐level arsenic concentration (<5 μg/L), were included in the study. High‐performance liquid chromatography and inductively coupled plasma mass spectrometry were used for the measurement. The NMSC group was found to have significantly higher levels of total inorganic arsenic, trivalent and pentavalent arsenic and monomethylarsonic acid than the control group. Total arsenic, organic arsenic and dimethylarsonic acid levels were lower in the NMSC group. We suggest that inorganic arsenic species, trivalent arsenic and pentavalent arsenic may influence the prevalence of NMSC, in spite of these levels being lower than the Agency for Toxic Substances and Disease Registry‐recommended standard or the levels reported by other highly contaminated areas and neighboring countries in East Asia. Furthermore, it also suggests that total arsenic level cannot represent the risk of NMSC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28815697</pmid><doi>10.1111/1346-8138.13993</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1429-8779</orcidid></addata></record> |
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| subjects | Aged Aged, 80 and over Arsenic Arsenic - toxicity Arsenicals - urine basal cell carcinoma Biopsy Case-Control Studies Creatinine Female High-performance liquid chromatography Humans Male Mass spectroscopy Melanoma Middle Aged non‐melanoma skin cancer Risk assessment Skin cancer Skin Neoplasms - chemically induced speciation Species squamous cell carcinoma Toxicity |
| title | Case–control study of chronic low‐level exposure of inorganic arsenic species and non‐melanoma skin cancer |
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