Exploration of Macroporous Polymeric Sponges As Drug Carriers

Exploration of Macroporous Polymeric Sponges As Drug Carriers

Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g...

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Veröffentlicht in:Biomacromolecules 2017-10, Vol.18 (10), p.3215-3221
Hauptverfasser: Duan, Gaigai, Bagheri, Amir Reza, Jiang, Shaohua, Golenser, Jacob, Agarwal, Seema, Greiner, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
Artemisinins - chemistry
Drug Carriers - chemistry
Drug Liberation
Polymers - chemistry
Porosity
Volatilization
Xylenes - chemistry
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Zusammenfassung:Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g for the sponges with densities of 3.5 and 6.0 mg/cm3, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (
ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.7b00852