Non invasive high resolution in vivo imaging of α-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka

A novel transparent stock of medaka ( Oryzias latipes; STII), homozygous recessive for all four pigments (iridophores, xanthophores, leucophores, melanophores), permits transcutaneous, high resolution (

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Bibliographische Detailangaben
Veröffentlicht in:	Aquatic toxicology 2008-01, Vol.86 (1), p.20-37
Hauptverfasser:	Hardman, Ron, Kullman, Seth, Yuen, Bonny, Hinton, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Naphthylisothiocyanate - toxicity Animals ANIT Antibodies - metabolism Apoptosis Bile Ducts, Intrahepatic - drug effects Bile Ducts, Intrahepatic - pathology Bile Ducts, Intrahepatic - ultrastructure Biliary Biliary toxicity Blood Vessels - drug effects cytotoxicity Epithelial Cells - cytology Epithelial Cells - drug effects Fish fluorescence Fluorescent Dyes - analysis Hepatobiliary Hepatotoxicity image analysis Image Processing, Computer-Assisted Imaging, Three-Dimensional - veterinary immunohistochemistry laboratory animals Liver Liver - blood supply Liver - drug effects Liver - pathology Liver - ultrastructure Medaka microscopy Microscopy, Confocal - veterinary Models, Animal Oryzias - genetics Oryzias - physiology Oryzias latipes Phenotype Piscine liver thiocyanates Toxicity Toxicology xenobiotics α-Naphthylisothiocyanate
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Beschreibung
Zusammenfassung:	A novel transparent stock of medaka ( Oryzias latipes; STII), homozygous recessive for all four pigments (iridophores, xanthophores, leucophores, melanophores), permits transcutaneous, high resolution (
ISSN:	0166-445X 1879-1514
DOI:	10.1016/j.aquatox.2007.09.014