A new anthracycline-type metabolite from Streptomyces sp. NEAU-L3

A new anthracycline-type metabolite, designated as tetracenoquinocin A (1), was isolated from the fermentation broth of Streptomyces sp. NEAU-L3. Its structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from th...

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Veröffentlicht in:	Journal of antibiotics 2017-10, Vol.70 (10), p.1026-1028
Hauptverfasser:	Lu, Chang, Zhao, Yue, Jia, Wei-Qi, Zhang, Hui, Qi, Huan, Xiang, Wen-Sheng, Wang, Ji-Dong, Wang, Xiang-Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/153 692/308/153 Anthracycline Anthracyclines - chemistry Anthracyclines - isolation & purification Antibiotics Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Bacteriology Biological Products - chemistry Biological Products - isolation & purification Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Cytotoxicity Drinking water Fermentation Glucose Humans Hydrocarbons Inhibitory Concentration 50 Life Sciences Medicinal Chemistry Metabolites Microbiology NMR Nuclear magnetic resonance Organic Chemistry Spectrometry, Mass, Electrospray Ionization Spectrum Analysis Streptomyces Streptomyces - chemistry Tumor cell lines Two dimensional analysis
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Zusammenfassung:	A new anthracycline-type metabolite, designated as tetracenoquinocin A (1), was isolated from the fermentation broth of Streptomyces sp. NEAU-L3. Its structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. Compound 1 showed potent cytotoxic activity against three cancer cell lines (HepG2, A549, HCT-116) with IC 50 values of 5.57, 24.30 and 20.82 μ M , respectively.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2017.95