Serotonergic modulation of synaptic transmission and action potential firing in frog motoneurons

Frog spinal neurons receive a prominent innervation from the bulbar serotonergic nuclear complex. We used an isolated spinal cord preparation to examine the effect of serotonin (5-hydroxytryptamine, 5-HT) receptor activation on segmental and descending monosynaptic excitatory inputs to frog lumbar m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2006-08, Vol.1102 (1), p.71-77
Hauptverfasser:	Ovsepian, Saak V., Vesselkin, Nikolai P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Action Potentials - radiation effects Animals Anura Dose-Response Relationship, Radiation Electric Stimulation - methods EPSP-spike Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects In Vitro Techniques Motor Neurons - drug effects Motor Neurons - physiology Motor Neurons - radiation effects Population discharge Rana ridibunda Serotonin Serotonin - pharmacology Spinal cord Spinal Cord - cytology Synaptic Transmission - drug effects Synaptic Transmission - physiology Synaptic Transmission - radiation effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Frog spinal neurons receive a prominent innervation from the bulbar serotonergic nuclear complex. We used an isolated spinal cord preparation to examine the effect of serotonin (5-hydroxytryptamine, 5-HT) receptor activation on segmental and descending monosynaptic excitatory inputs to frog lumbar motoneurons. Bath-application of 5-HT (0.05 mM) caused a significant reduction in the peak amplitude of segmental EPSP elicited by dorsal root (DR) stimulation ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2006.04.035