Longitudinal Changes in Segmental Aortic Stiffness Determined by Cardiac Magnetic Resonance in Children and Young Adults With Connective Tissue Disorders (the Marfan, Loeys-Dietz, and Ehlers-Danlos Syndromes, and Nonspecific Connective Tissue Disorders)

Aortic stiffness measured by cardiac magnetic resonance (CMR) in connective tissue disorder (CTD) patients has been previously shown to be abnormal and to be associated with adverse aortic outcomes. The rate of increase in aortic stiffness with normal aging has been previously described. However, lo...

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Veröffentlicht in:	The American journal of cardiology 2017-10, Vol.120 (7), p.1214-1219
Hauptverfasser:	Merlocco, Anthony, Lacro, Ronald V., Gauvreau, Kimberlee, Rabideau, Nicole, Singh, Michael N., Prakash, Ashwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Age Aging Aorta Aorta - pathology Aorta - physiopathology Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Blood pressure Child Child, Preschool Children Children & youth Connective Tissue Diseases - diagnosis Connective Tissue Diseases - physiopathology Connective tissues Coronary vessels Disorders Ehlers-Danlos syndrome Ehlers-Danlos Syndrome - diagnosis Ehlers-Danlos Syndrome - physiopathology Female Follow-Up Studies Growth factors Heart Heart diseases Humans Infant Loeys-Dietz Syndrome - diagnosis Loeys-Dietz Syndrome - physiopathology Magnetic resonance Magnetic Resonance Imaging, Cine - methods Male Marfan syndrome Marfan Syndrome - diagnosis Marfan Syndrome - physiopathology Mercury Middle Aged Mutation NMR Nuclear magnetic resonance Pathogenesis Patients Pediatrics Resonance Retrospective Studies Severity of Illness Index Stiffness Surgery Vascular Stiffness Young Adult Young adults
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Zusammenfassung:	Aortic stiffness measured by cardiac magnetic resonance (CMR) in connective tissue disorder (CTD) patients has been previously shown to be abnormal and to be associated with adverse aortic outcomes. The rate of increase in aortic stiffness with normal aging has been previously described. However, longitudinal changes in aortic stiffness have not been characterized in CTD patients. We examined longitudinal changes in CMR-derived aortic stiffness in children and young adults with CTDs. A retrospective analysis of 50 children and young adults (median age, 20 years; range, 0.2 to 49; 40%
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2017.06.064