MicroRNAs, promising biomarkers in the diagnosis of Xp11 translocation RCC

Research shows that clinical symptoms, image characteristics, and pathologic characteristics of Xp11 translocation RCC are similar to other RCC subtypes [3,4]. [...]immunohistochemistry and cytogenetic analysis are quite important in histologic type or molecular underpinning of Xp11 translocation RCC. [...]these above-mentioned studies remind us that microRNA expression profiles are capable not only of distinguishing between Xp11 translocation RCC and normal tissue samples but also of classifying the other RCC subtypes. There is also some overlap in miRNA expression with Xp11 translocation RCC and clear cell papillary RCC. [...]it is a matter of great urgency to confirm characteristic miRNAs that specifically distinguish Xp11 translocation RCC. 1 P. Argani, MiT family translocation renal cell carcinoma, Semin Diagn Pathol, Vol. 32, 2015, 103-113 2 K. Pivovarcikova, P. Grossman, R. Alaghehbandan, M. Sperga, M. Michal, O. Hes, TFE3-fusion variant analysis defines specific clinicopathologic associations among Xp11 translocation cancers, Am J Surg Pathol, Vol. 41, 2017, 138-140 3 N. Liu, Z. Wang, W. Gan, PLoS One, Vol. 11, 2016, e0166897 4 H.B. Armah, A.V. Parwani, Xp11.2 translocation renal cell carcinoma, Arch Pathol Lab Med, Vol. 134, 2010, 124-129 5 L. Marchionni, M. Hayashi, E. Guida, MicroRNA expression profiling of Xp11 renal cell carcinoma, um, athol, Vol. 67, 2017, 18-29 6 V. Petrozza, A. Carbone, T. Bellissimo, Oncogenic MicroRNAs characterization in clear cell renal cell carcinoma, Int J Mol Sci, Vol. 16, 2015, 29219-29225 7 H. Liu, A.R. Brannon, A.R. Reddy, Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell renal cell carcinoma, BMC Syst Biol, Vol. 4, 2010, 51 8 X. Shu, M.A. Hildebrandt, J. Gu, MicroRNA profiling in clear cell renal cell carcinoma tissues potentially links tumorigenesis and recurrence with obesity, Br J Cancer, Vol. 116, 2017, 77-84 9 E. Munari, L. Marchionni, A. Chitre, Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma, um, athol, Vol. 45, 2014, 1130-1138 10 S. Wach, E. Nolte, A. Theil, MicroRNA profiles classify papillary renal cell carcinoma subtypes, Br J Cancer, Vol. 109, 2013, 714-722 11 D.P. Bartel, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, Vol. 116, 2004, 281-297