Structural Features of Lipopolysaccharide from Rickettsia Typhi: The Causative Agent of Endemic Typhus

: Rickettsia typhi causes endemic typhus, a relatively mild, acute febrile illness characterized by headache and macular rash. It is maintained in rodents and transmitted to humans by flea Xenopsylla cheopis. R. typhi contains a lipopolysaccharide thought to display a noticeable antigenic activity....

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2005-12, Vol.1063 (1), p.259-260
Hauptverfasser:	FODOROVA, MARCELA, VADOVIC, PAVOL, SKULTETY, LUDOVIT, SLABA, KATARINA, TOMAN, RUDOLF
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrate Conformation Carbohydrate Sequence composition Electrophoresis, Polyacrylamide Gel endemic typhus Gas Chromatography-Mass Spectrometry Humans lipopolysaccharide Lipopolysaccharides - chemistry Lipopolysaccharides - isolation & purification Lipopolysaccharides - toxicity Rickettsia typhi Rickettsia typhi - chemistry Rickettsia typhi - immunology Spectrometry, Mass, Electrospray Ionization structure Typhus, Endemic Flea-Borne - metabolism Typhus, Endemic Flea-Borne - microbiology Xenopsylla cheopis
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Beschreibung
Zusammenfassung:	: Rickettsia typhi causes endemic typhus, a relatively mild, acute febrile illness characterized by headache and macular rash. It is maintained in rodents and transmitted to humans by flea Xenopsylla cheopis. R. typhi contains a lipopolysaccharide thought to display a noticeable antigenic activity. We examined its structural features and it appears that the O‐specific chain of the R. typhi LPS is composed mainly of the alternating Glc and QuiNAc residues linked by 1→4 bonds.
ISSN:	0077-8923 1749-6632
DOI:	10.1196/annals.1355.041