MicroRNA‐492 overexpression involves in cell proliferation, migration, and radiotherapy response of cervical squamous cell carcinomas

MicroRNAs (miRNAs) are small non‐coding RNA that target protein‐coding mRNAs at the post‐transcriptional level. The aim of this study was to define the role of miR‐492 in cervical squamous cell carcinomas. After microRNA profiling and comparison, we firstly detected miR‐492 expression in 104 tumor t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular carcinogenesis 2018-01, Vol.57 (1), p.32-43
Hauptverfasser:	Liu, Mei, An, Jusheng, Huang, Manni, Wang, Liming, Tu, Binbin, Song, Yan, Ma, Kai, Wang, Yu, Wang, Shuren, Zhu, Hongxia, Xu, Ningzhi, Wu, Lingying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Cervical cancer Cervical carcinoma Cervix Chemoradiotherapy Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Irradiation Lymph Lymph nodes Lymphatic Metastasis Lymphatic system Metastases Metastasis Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - genetics Middle Aged miRNA miR‐492 Neoplasm Invasiveness Non-coding RNA pelvic lymph node Post-transcription Prognosis Radiation Radiation therapy radiosensitivity Sensitivity Squamous cell carcinoma Stromelysin 2 TIMP2 Tissue inhibitor of metalloproteinase 2 Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - metabolism Tissues Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	MicroRNAs (miRNAs) are small non‐coding RNA that target protein‐coding mRNAs at the post‐transcriptional level. The aim of this study was to define the role of miR‐492 in cervical squamous cell carcinomas. After microRNA profiling and comparison, we firstly detected miR‐492 expression in 104 tumor tissues biopsies derived from advanced staged (FIGO IIB‐IIIB) cervical squamous cell carcinoma patients before receiving concomitant chemoradiotherapy and found miR‐492 expression was significantly higher in the specimens that were sensitive to concomitant chemoradiotherapy, as compared with insensitive cancer specimens (P
ISSN:	0899-1987 1098-2744
DOI:	10.1002/mc.22717