Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence
Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS- and ConA-stimul...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2005-12, Vol.140 (6), p.723-725 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Filimonov, P N Sukhenko, T G Papantonopulo, A N Gavrilova, N I Shkurupii, V A |
| description | Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS- and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation further progress of liver fibrosis was observed in young mice. |
| doi_str_mv | 10.1007/s10517-006-0066-7 |
| format | Article |
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Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS- and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation further progress of liver fibrosis was observed in young mice.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-006-0066-7</identifier><identifier>PMID: 16848236</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Age Factors ; Animals ; Cells, Cultured ; Concanavalin A - metabolism ; Fibrosis - pathology ; Heroin - pharmacology ; Lipopolysaccharides - metabolism ; Liver - metabolism ; Liver - pathology ; Mice ; Mice, Inbred CBA ; Spleen - cytology ; Substance Withdrawal Syndrome ; Substance-Related Disorders ; Time Factors</subject><ispartof>Bulletin of experimental biology and medicine, 2005-12, Vol.140 (6), p.723-725</ispartof><rights>Springer Science+Business Media, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c80fe2dddbcf3f43958692166c9b22cb31b9ed589cda440cbee6aea196ddf77f3</citedby><cites>FETCH-LOGICAL-c357t-c80fe2dddbcf3f43958692166c9b22cb31b9ed589cda440cbee6aea196ddf77f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16848236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filimonov, P N</creatorcontrib><creatorcontrib>Sukhenko, T G</creatorcontrib><creatorcontrib>Papantonopulo, A N</creatorcontrib><creatorcontrib>Gavrilova, N I</creatorcontrib><creatorcontrib>Shkurupii, V A</creatorcontrib><title>Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. 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| ispartof | Bulletin of experimental biology and medicine, 2005-12, Vol.140 (6), p.723-725 |
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| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Age Factors Animals Cells, Cultured Concanavalin A - metabolism Fibrosis - pathology Heroin - pharmacology Lipopolysaccharides - metabolism Liver - metabolism Liver - pathology Mice Mice, Inbred CBA Spleen - cytology Substance Withdrawal Syndrome Substance-Related Disorders Time Factors |
| title | Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence |
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