Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence

Level of liver fibrosis and immune status of mice of different age after heroin treatment and long abstinence

Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS- and ConA-stimul...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2005-12, Vol.140 (6), p.723-725
Hauptverfasser: Filimonov, P N, Sukhenko, T G, Papantonopulo, A N, Gavrilova, N I, Shkurupii, V A
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Animals
Cells, Cultured
Concanavalin A - metabolism
Fibrosis - pathology
Heroin - pharmacology
Lipopolysaccharides - metabolism
Liver - metabolism
Liver - pathology
Mice
Mice, Inbred CBA
Spleen - cytology
Substance Withdrawal Syndrome
Substance-Related Disorders
Time Factors
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Zusammenfassung:Young and middle-aged CBA mice were injected with "street" heroin in increasing doses for 14 days. Volume density of perisinusoid argirophilic fibers increased in both age groups (the increase being more pronounced in middle-aged mice), while the levels of spontaneous, LPS- and ConA-stimulated splenocyte proliferation decreased in young mice. Six months after heroin discontinuation further progress of liver fibrosis was observed in young mice.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0066-7