H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns

We describe the implementation of a system of immobilised enzymes for H2-driven NADH recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for en...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (71), p.9839-9841
Hauptverfasser: Zor, Ceren, Reeve, Holly A, Quinson, Jonathan, Thompson, Lisa A, Lonsdale, Thomas H, Dillon, Frank, Grobert, Nicole, Vincent, Kylie A
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We describe the implementation of a system of immobilised enzymes for H2-driven NADH recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for enantioselective ketone reduction and reductive amination.
ISSN:1364-548X
DOI:10.1039/c7cc04465h