Virulence May Determine the Necessary Duration and Dosage of Oseltamivir Treatment for Highly Pathogenic A/Vietnam/1203/04 Influenza Virus in Mice

BackgroundControl of highly pathogenic avian H5N1 influenza viruses is a major public-health concern. Antiviral drugs could be the only option early in the pandemic MethodsBALB/c mice were given oseltamivir (0.1, 1, or 10 mg/kg/day) twice daily by oral gavage; the first dose was given 4 h before ino...

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Veröffentlicht in:	The Journal of infectious diseases 2005-08, Vol.192 (4), p.665-672
Hauptverfasser:	Yen, Hui-Ling, Monto, Arnold S., Webster, Robert G., Govorkova, Elena A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - administration & dosage Animals Antiviral Agents - administration & dosage Antivirals Biological and medical sciences Brain - virology Cell Line Dosage Dose-Response Relationship, Drug Drug Administration Schedule Female Fundamental and applied biological sciences. Psychology Guanidines H5N1 subtype influenza A virus Infectious diseases Influenza A virus Influenza A virus - drug effects Influenza A virus - pathogenicity Influenza virus Inhibitory Concentration 50 Inoculation Lung - virology Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Orthomyxoviridae Orthomyxoviridae Infections - drug therapy Oseltamivir Placebos Pyrans Sialic Acids - pharmacology Virology Virulence Virus Replication - drug effects Viruses Zanamivir
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Zusammenfassung:	BackgroundControl of highly pathogenic avian H5N1 influenza viruses is a major public-health concern. Antiviral drugs could be the only option early in the pandemic MethodsBALB/c mice were given oseltamivir (0.1, 1, or 10 mg/kg/day) twice daily by oral gavage; the first dose was given 4 h before inoculation with H5N1 A/Vietnam/1203/04 (VN1203/04) virus. Five- and 8-day regimens were evaluated ResultsOseltamivir produced a dose-dependent antiviral effect against VN1203/04 in vivo (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/432008