The concept of platinum sensitivity could be applied to recurrent cervical cancer: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group

The concept of platinum sensitivity could be applied to recurrent cervical cancer: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group

Purpose This study aimed at evaluating the applicability of the concept of platinum sensitivity to recurrent cervical cancer. Methods The clinical information of patients with recurrent cervical cancer, who were initially treated with platinum-based chemotherapy and received second-line platinum-bas...

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Veröffentlicht in:Cancer chemotherapy and pharmacology 2017-10, Vol.80 (4), p.697-705
Hauptverfasser: Takekuma, Munetaka, Mori, Keita, Iida, Tetsuji, Kurihara, Kazuko, Saitou, Motoaki, Tokunaga, Hideki, Kawana, Kei, Ikeda, Masae, Satoh, Toyomi, Saito, Toshiaki, Miyagi, Etsuko, Nagai, Yutaka, Furusawa, Akiko, Kawano, Yoshiaki, Kawano, Kouichiro, Tabata, Tsutomu, Ota, Yukinobu, Hayase, Ryoji, Mikami, Mikio, Sugiyama, Toru
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - pharmacology
Cancer
Cancer Research
Cervical cancer
Cervix
Chemotherapy
Disease-Free Survival
Drug Resistance, Neoplasm
Female
Health care facilities
Humans
Japan
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Oncology
Original Article
Patients
Pharmacology/Toxicology
Platinum
Platinum Compounds - administration & dosage
Platinum Compounds - pharmacology
Prognosis
Retrospective Studies
Sensitivity
Sensitivity analysis
Statistical analysis
Survival
Survival Rate
Time Factors
Treatment Outcome
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - pathology
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Zusammenfassung:Purpose This study aimed at evaluating the applicability of the concept of platinum sensitivity to recurrent cervical cancer. Methods The clinical information of patients with recurrent cervical cancer, who were initially treated with platinum-based chemotherapy and received second-line platinum-based chemotherapy at the time of recurrence between January 2008 and December 2012, was retrospectively reviewed. Results A total of 677 patients from 71 medical centers were analyzed. The median overall survival (OS) for patients with platinum-free interval (PFI) of
ISSN:0344-5704
1432-0843
DOI:10.1007/s00280-017-3402-x