One-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling

One-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling

We describe the first one-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling between readily available aryl (pseudo)halides and activated alkyl chlorides. This method streamlines the synthesis of diaryl methanes, α-aryl carbonyls and allyl aryl compounds, substructures that are commonly found in l...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-08, Vol.53 (67), p.9364-9367
Hauptverfasser: Whitaker, Luke, Harb, Hassan Y, Pulis, Alexander P
Format: Artikel
Sprache:eng
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Zusammenfassung:We describe the first one-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling between readily available aryl (pseudo)halides and activated alkyl chlorides. This method streamlines the synthesis of diaryl methanes, α-aryl carbonyls and allyl aryl compounds, substructures that are commonly found in life changing drug molecules.
ISSN:1364-548X
DOI:10.1039/c7cc05037b