Palladium-Catalyzed Direct C–H Trifluoroethylation of Aromatic Amides

Palladium-Catalyzed Direct C–H Trifluoroethylation of Aromatic Amides

A simple and direct C–H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been do...

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Veröffentlicht in:Organic letters 2017-08, Vol.19 (16), p.4223-4226
Hauptverfasser: Maraswami, Manikantha, Pankajakshan, Sreekumar, Chen, Gang, Loh, Teck-Peng
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple and direct C–H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01859