NAD + Deficits in Age-Related Diseases and Cancer

The phenomenon of aging has gained widespread attention in recent times. Although significant advances have been made to better understand aging and its related pathologies including cancer, there is not yet a clear mechanism explaining why diseases and cancer are inherent parts of the aging process...

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Veröffentlicht in:Trends in Cancer 2017-08, Vol.3 (8), p.593-610
Hauptverfasser: Garrido, Amanda, Djouder, Nabil
Format: Artikel
Sprache:eng
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Zusammenfassung:The phenomenon of aging has gained widespread attention in recent times. Although significant advances have been made to better understand aging and its related pathologies including cancer, there is not yet a clear mechanism explaining why diseases and cancer are inherent parts of the aging process. Finding a unifying equation that could bridge aging and its related diseases would allow therapeutic development and solve an immense human health problem to live longer and better. In this review, we discuss NAD reduction as the central mechanism that may connect aging to its related pathologies and cancer. NAD boosters would ensure and ameliorate health quality during aging.
ISSN:2405-8033
2405-8025
DOI:10.1016/j.trecan.2017.06.001