Talking about a Revolution: The Impact of Site-Specific Recombinases on Genetic Analyses in Mice

Talking about a Revolution: The Impact of Site-Specific Recombinases on Genetic Analyses in Mice

Site-specific recombinase systems (Cre- loxP, Flp- FRT, and φC31- att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene func...

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Veröffentlicht in:Developmental Cell 2004, Vol.6 (1), p.7-28
Hauptverfasser: Branda, Catherine S., Dymecki, Susan M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Lineage - genetics
DNA Nucleotidyltransferases - genetics
Flp recombinase
FRT gene
Gene Expression Regulation - genetics
Genome
Integrases - genetics
loxP gene
Mice - genetics
Models, Animal
Molecular Biology - methods
Molecular Biology - trends
Mutagenesis, Site-Directed - genetics
Recombinases - genetics
Recombination, Genetic - genetics
Viral Proteins - genetics
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Zusammenfassung:Site-specific recombinase systems (Cre- loxP, Flp- FRT, and φC31- att) are transforming both forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be induced in vitro or in vivo, these systems have incited a wave of new biology, advancing our understanding of gene function, genetic relationships, development, and disease.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(03)00399-X