Production of 5 alpha -Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA sub(A) Miniature IPSCs in Lamina II of the Spinal Cord

Production of 5 alpha -Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA sub(A) Miniature IPSCs in Lamina II of the Spinal Cord

In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA sub(A) and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the propertie...

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Veröffentlicht in:The Journal of neuroscience 2004-01, Vol.24 (4), p.907-915
Hauptverfasser: Keller, A F, Breton, J-D, Schlichter, R, Poisbeau, P
Format: Artikel
Sprache:eng
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Zusammenfassung:In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA sub(A) and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of miniature IPSCs (mIPSCs) mediated by activation of GABA sub(A) and glycine receptors in immature (
ISSN:0270-6474
DOI:10.1523/JNEUROSCI.4642-03.2004