Novel chemical probes for the investigation of nonribosomal peptide assembly

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2017, Vol.53 (52), p.7088-7091
Hauptverfasser:	Ho, Y T Candace, Leng, Daniel J, Ghiringhelli, Francesca, Wilkening, Ina, Bushell, Dexter P, Kostner, Otto, Riva, Elena, Havemann, Judith, Passarella, Daniele, Tosin, Manuela
Format:	Artikel
Sprache:	eng
Schlagworte:	Assembly Echinomycin - biosynthesis Echinomycin - chemistry Flexibility Molecular Probes - analysis Molecular Probes - chemistry Molecular Structure Pathways Paving Peptides Substrates
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c7cc02427d