Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for bio...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-06, Vol.53 (53), p.7246-7249
Hauptverfasser: Ellis, S R, Soltwisch, J, Paine, M R L, Dreisewerd, K, Heeren, R M A
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical Research
Coupling
Imaging
Lasers
Lipids
Lipids - analysis
Mass spectrometers
Resolution
Sensitivity enhancement
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Zusammenfassung:Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc02325a