Multinuclear zinc bisamidinate catalyzed asymmetric alkylation of α-ketoesters and its unique chemoselectivity

Multinuclear zinc bisamidinate catalyzed asymmetric alkylation of α-ketoesters and its unique chemoselectivity

The multinuclear Zn-bisamidinate catalyzed enantioselective addition of Et Zn to α-ketoesters has been developed. The steric tuning of two amidinate units as well as multiple coordination on the Zn atoms play a key role in achieving high enantioselectivity (up to 98% ee) and unique chemoselectivity....

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-07, Vol.53 (54), p.7513-7516
Hauptverfasser: Yamanaka, Masahiro, Inaba, Masamitsu, Gotoh, Ryo, Ueki, Yoshiyuki, Matsui, Kenichiro
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Alkylation
Asymmetry
Catalysts
Tuning
Zinc
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Beschreibung
Zusammenfassung:The multinuclear Zn-bisamidinate catalyzed enantioselective addition of Et Zn to α-ketoesters has been developed. The steric tuning of two amidinate units as well as multiple coordination on the Zn atoms play a key role in achieving high enantioselectivity (up to 98% ee) and unique chemoselectivity. The present catalyst exhibited the preferential alkylation of α-ketoesters even in the presence of aldehydes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc01736g