Direct C-2 acylation of indoles with toluene derivatives via Pd( ii )-catalyzed C–H activation

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert -butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.

Bibliographische Detailangaben

Veröffentlicht in:	RSC advances 2017-01, Vol.7 (52), p.32559-32563
Hauptverfasser:	Zhao, Yaping, Sharma, Upendra K., Schrӧder, Felix, Sharma, Nandini, Song, Gonghua, Van der Eycken, Erik V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Acylation Additives Derivatives Indoles Oxidants Oxidizing agents Toluene
Online-Zugang:	Volltext
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