Direct C-2 acylation of indoles with toluene derivatives via Pd( ii )-catalyzed C–H activation
A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert -butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.
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Veröffentlicht in: | RSC advances 2017-01, Vol.7 (52), p.32559-32563 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with
tert
-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/C7RA06004A |