Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp

Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp

A new cyclic depsipeptide, rakicidin F ( 1 ), along with the known compound rakicidin C ( 2 ), was isolated from the fermentation broth of the marine sponge-derived actinomycete strain Streptomyces sp. GKU 220. Their structures were elucidated by interpreting the HRFABMS and NMR spectroscopic data....

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Veröffentlicht in:Journal of antibiotics 2018-01, Vol.71 (1), p.139-141
Hauptverfasser: Kitani, Shigeru, Ueguchi, Tatsuya, Igarashi, Yasuhiro, Leetanasaksakul, Kantinan, Thamchaipenet, Arinthip, Nihira, Takuya
Format: Artikel
Sprache:eng
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631/326/252/22/1290
Antibiotics
Antiinfectives and antibacterials
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Biotechnology
Carbon
Fermentation
Life Sciences
Medicinal Chemistry
Microbiology
NMR
Nuclear magnetic resonance
Organic Chemistry
Streptomyces
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Zusammenfassung:A new cyclic depsipeptide, rakicidin F ( 1 ), along with the known compound rakicidin C ( 2 ), was isolated from the fermentation broth of the marine sponge-derived actinomycete strain Streptomyces sp. GKU 220. Their structures were elucidated by interpreting the HRFABMS and NMR spectroscopic data. Rakicidin F ( 1 ) showed growth inhibitory activity against bacteria.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2017.92