Cancer in the Renaissance court of Naples

Cancer in the Renaissance court of Naples

Strong immunoreactivity for pan-cytokeratin was shown and DNA analysis of KRAS exons 1-2 showed the presence of a mutation that is characteristic of sporadic colorectal cancer and associated with exposure to natural carcinogens that would have been present in the diet of the time.3 The histological...

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Veröffentlicht in:The lancet oncology 2017-08, Vol.18 (8), p.e432-e432
Hauptverfasser: Gaeta, Raffaele, Giuffra, Valentina, Fornaciari, Gino
Format: Artikel
Sprache:eng
Schlagworte:
Adenoma
Aged
Biomarkers, Tumor - genetics
Biomarkers, Tumor - history
Cancer
Carcinogens
Colorectal carcinoma
Cytokeratin
Deoxyribonucleic acid
DNA
Exons
Female
Genetic Predisposition to Disease
Health risk assessment
Histology
History, 15th Century
History, 16th Century
Humans
Immunoreactivity
Italy
K-Ras protein
Male
Middle Aged
Mucosa
Mummies - history
Neoplasms - genetics
Neoplasms - history
Neoplasms - pathology
Phenotype
Tumors
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Zusammenfassung:Strong immunoreactivity for pan-cytokeratin was shown and DNA analysis of KRAS exons 1-2 showed the presence of a mutation that is characteristic of sporadic colorectal cancer and associated with exposure to natural carcinogens that would have been present in the diet of the time.3 The histological study of the natural mummy of Prince Luigi Carafa of Stigliano (1511-76) revealed an extraordinarily well preserved colon mucosa with an evident villous adenoma and strong immune positivity for...
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(17)30464-3