Prognostic Value of Ventricular Wall Motion Score and Global Registry of Acute Coronary Events Score in Patients With Acute Myocardial Infarction

The aim of this study was to evaluate the prognostic values of ventricular wall motion score (WMS) and Global Registry of Acute Coronary Events (GRACE) score in patients with acute myocardial infarction (AMI) in a 12-month single-center prospective cohort. Consecutive inpatients diagnosed with AMI in the Department of Cardiology of The Second Affiliated Hospital of Soochow University from September 2012 through March 2015 were enrolled in this study. Echocardiography was issued to all subjects to calculate WMS within 24 hours after admission, and GRACE score of each patient was obtained simultaneously. During a 12-month follow-up period, all major adverse cardiac events (MACE) were recorded. After 12 months of observation, 124 of 635 patients with AMI developed MACE. The WMS (23.70 ± 3.80 versus 20.47 ± 3.25) and GRACE score (185.59 ± 45.16 versus 152.19 ± 36.51) were significantly higher in patients with MACE than those without MACE (P < 0.05). Survival analysis using Cox regression revealed that both WMS (95% CI: 1.082-1.184, P < 0.05) and GRACE score (95% CI: 1.010-1.021, P < 0.05) independently predicted MACE. The receiver operating curve curve analysis showed that the area under curve of WMS, GRACE score and the combination of WMS and GRACE score were 0.768 (P < 0.05), 0.718 (P < 0.05) and 0.812 (P < 0.05), respectively. WMS and GRACE score were independent predictors of MACE in patients with AMI in 12-month follow-up, and the combined application of WMS and GRACE score can significantly improve the predictive value.