Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery

The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates for human autoimmune disease in clinical trials. Examples from own work in a primate multiple sclerosis (MS) model illustrate that important le...

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Veröffentlicht in:Clinical pharmacology and therapeutics 2018-02, Vol.103 (2), p.262-270
Hauptverfasser: 't Hart, Bert A., Laman, Jon D., Kap, Yolanda S.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates for human autoimmune disease in clinical trials. Examples from own work in a primate multiple sclerosis (MS) model illustrate that important lessons can be learned from a critical reassessment of failed drugs in the animal model, which can help improve the animal model and better understand the targeted disease.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.801