Acid-Promoted DNA-Cleaving Activities and Total Synthesis of Varacin C

The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2002-11, Vol.124 (47), p.13972-13973
Hauptverfasser:	Lee, Alex H. F, Chen, Jian, Liu, Dongsheng, Leung, Thomas Y. C, Chan, Albert S. C, Li, Tianhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - pharmacology Biological and medical sciences DNA Damage DNA, Circular - drug effects DNA, Circular - metabolism Dna, deoxyribonucleoproteins DNA, Superhelical - drug effects DNA, Superhelical - metabolism Drug Interactions Ethylamines - chemical synthesis Ethylamines - pharmacology Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Nucleic acids Oxidation-Reduction Sulfhydryl Compounds - pharmacology Sulfides - chemical synthesis Sulfides - pharmacology Tumor Cells, Cultured varacin C
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Beschreibung
Zusammenfassung:	The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja020531i