Synergistic Effects of SAM and Selenium Compounds on Proliferation, Migration and Adhesion of HeLa Cells

To determine the antitumor activities and molecular mechanism of selenium compounds in HeLa cells. Western blotting was used to detect ERK and AKT activation in HeLa cells induced by selenium compounds selenomethionine (SeMet), methylselenocysteine (MeSeCys) and methylseleninic acids (MeSeA). Using...

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Veröffentlicht in:	Anticancer research 2017-08, Vol.37 (8), p.4433-4441
Hauptverfasser:	Sun, Licui, Zhang, Jianxin, Yang, Qiu, Si, Yang, Liu, Yiqun, Wang, Qin, Han, Feng, Huang, Zhenwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Drug Synergism Female Gene Expression Regulation, Neoplastic - drug effects HeLa Cells Humans MAP Kinase Signaling System - drug effects Mice Proto-Oncogene Proteins c-akt - metabolism S-Adenosylmethionine - administration & dosage S-Adenosylmethionine - pharmacology Selenium Compounds - administration & dosage Selenium Compounds - pharmacology Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism Xenograft Model Antitumor Assays
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Zusammenfassung:	To determine the antitumor activities and molecular mechanism of selenium compounds in HeLa cells. Western blotting was used to detect ERK and AKT activation in HeLa cells induced by selenium compounds selenomethionine (SeMet), methylselenocysteine (MeSeCys) and methylseleninic acids (MeSeA). Using MTT, wound-healing and Matrigel adhesion assays, the antitumor effects of SAM and selenium compounds were evaluated in HeLa cells. MeSeA inhibited ERK and AKT signaling pathways and suppressed the proliferation (p
ISSN:	0250-7005 1791-7530
DOI:	10.21873/anticanres.11838