Hepatitis C virus subtype 3a was introduced in the USSR in the early 1980s

Hepatitis C virus subtype 3a was introduced in the USSR in the early 1980s

A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 29...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of general virology 2017-08, Vol.98 (8), p.2079-2087
Hauptverfasser: Manuylov, Victor A, Chub, Elena V, Kichatova, Vera S, Soboleva, Natalya V, Isaeva, Olga V, Zamyatnin, Jr, Andrey A, Netesov, Sergey V
Format: Artikel
Sprache:eng
Schlagworte:
Genotype
Hepacivirus - classification
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C - epidemiology
Hepatitis C - virology
Humans
Molecular Epidemiology
Phylogeny
USSR - epidemiology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A total of 2120 nucleotide sequences of the NS5b region of HCV subtype 3a were analysed, including 310 strains derived from former republics of the USSR (Azerbaijan, Estonia, Lithuania, Russia, Tajikistan and Uzbekistan). Among the viral isolates collected from former regions of the Soviet Union, 294 strains formed 3 sustained phylogenetic clusters, with each having a common origin. Phylodynamic analysis demonstrated that the most recent common ancestors of the current strains inside the three clusters were introduced into the USSR population in 1981±1, 1984±2 and 1985±2, respectively (the confidence intervals were calculated using Student's t-distribution, P
ISSN:0022-1317
1465-2099
DOI:10.1099/jgv.0.000878