Effect of metformin on germ cell‐specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats

Summary The study was designed to evaluate the effects of metformin on apoptosis and epididymal sperm quality in a rat testicular ischaemia/reperfusion (I/R) injury model. A total of 72 male rats were divided into four groups (n = 18 for each group): group 1 (sham‐operated group), group 2 (metformin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Andrologia 2018-03, Vol.50 (2), p.e12846-n/a
Hauptverfasser:	Ghasemnejad‐Berenji, M., Ghazi‐Khansari, M., Yazdani, I., Nobakht, M., Abdollahi, A., Ghasemnejad‐Berenji, H., Mohajer Ansari, J., Pashapour, S., Dehpour, A. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Antidiabetics Antioxidants Apoptosis Apoptosis - drug effects Caspase Caspase 3 - metabolism Caspase-3 Catalase Catalase - metabolism Disease Models, Animal Enzyme Activators - pharmacology Enzyme Activators - therapeutic use Epididymis - cytology Epididymis - drug effects Epididymis - pathology Glutathione peroxidase Humans In Situ Nick-End Labeling Ischemia Male Malondialdehyde Malondialdehyde - metabolism Metformin Metformin - pharmacology Metformin - therapeutic use Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - etiology Reperfusion Injury - physiopathology Rodents Seminiferous tubule Sperm Sperm Count Spermatic Cord Torsion - complications Spermatozoa - drug effects Spermatozoa - physiology Superoxide dismutase Testes testicular torsion/detorsion Testis - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary The study was designed to evaluate the effects of metformin on apoptosis and epididymal sperm quality in a rat testicular ischaemia/reperfusion (I/R) injury model. A total of 72 male rats were divided into four groups (n = 18 for each group): group 1 (sham‐operated group), group 2 (metformin group), group 3 (torsion/detorsion [T/D] + saline) and group 4 (T/D + 300 mg kg−1 metformin). Testicular torsion was achieved by rotating the right testis 720° in a clockwise direction for 1 hr. Tissue malondialdehyde (MDA) level and caspase‐3 activity increased and the activities of catalase, superoxide dismutase and glutathione peroxidase decreased in comparison with sham‐operated group 4 hr after detorsion (p
ISSN:	0303-4569 1439-0272
DOI:	10.1111/and.12846