Characterization of reassortant H1-subtype avian influenza viruses isolated from poultry in Zhejiang Province in China from 2013 to 2015

From 2013 to 2015, 32 H1-subtype avian influenza viruses (AIVs), H1N2 (n = 12), H1N3 (n = 14), H1N4 (n = 4) and H1N9 (n = 2), were isolated from poultry in Zhejiang Province in eastern China. These strains were characterized by whole-genome sequencing with subsequent phylogenetic analysis and geneti...

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Veröffentlicht in:	Archives of virology 2017-11, Vol.162 (11), p.3493-3500
Hauptverfasser:	Wu, Haibo, Lu, Rufeng, Peng, Xiuming, Liu, Fumin, Cheng, Linfang, Wu, Nanping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian flu Biomedical and Life Sciences Biomedicine Brief Report China - epidemiology Gene Expression Regulation, Viral Genomes Hemagglutinins - genetics Hemagglutinins - metabolism Infectious Diseases Influenza Influenza A virus - genetics Influenza in Birds - epidemiology Influenza in Birds - virology Medical Microbiology Pandemics Phylogenetics Phylogeny Poultry Reassortant Viruses - isolation & purification Retrospective Studies Virology
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Beschreibung
Zusammenfassung:	From 2013 to 2015, 32 H1-subtype avian influenza viruses (AIVs), H1N2 (n = 12), H1N3 (n = 14), H1N4 (n = 4) and H1N9 (n = 2), were isolated from poultry in Zhejiang Province in eastern China. These strains were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis of all eight viral genes showed that these strains clustered in the AIV Eurasian lineage. These strains were found to be minimally pathogenic in mice and were able to replicate in mice without prior adaptation. Continued surveillance is needed, considering the important role of poultry in AIV reassortment.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-017-3487-x