Intermediate Molecular Mass Hyaluronan and CD44 Receptor Interactions Enhance Neutrophil Phagocytosis and IL-8 Production via p38- and ERK1/2-MAPK Signalling Pathways

CD44 is a common leukocyte adhesion molecule expressed on the surface of various cells. Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. The binding of small molec...

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Veröffentlicht in:	Inflammation 2017-10, Vol.40 (5), p.1782-1793
Hauptverfasser:	Lu, Cheng-Hsun, Lin, Chia-Huei, Li, Ko-Jen, Shen, Chieh-Yu, Wu, Cheng-Han, Kuo, Yu-Min, Lin, Ting-Syuan, Yu, Chia-Li, Hsieh, Song-Chou
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Biomedical and Life Sciences Biomedicine CD44 antigen CD45 antigen Cell proliferation Cytoskeleton Cytoskeleton - metabolism Extracellular signal-regulated kinase HL-60 Cells Humans Hyaluronan Receptors - metabolism Hyaluronic acid Hyaluronic Acid - metabolism Immunology Interleukin 8 Interleukin-8 - biosynthesis Internal Medicine Leukocytes (polymorphonuclear) Lipopolysaccharides MAP kinase MAP Kinase Signaling System Neutrophils Neutrophils - immunology Original Article p38 Mitogen-Activated Protein Kinases - metabolism Pathology Phagocytosis Pharmacology/Toxicology Phosphorylation Polymerization Protein Binding Rheumatology Signal Transduction
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Beschreibung
Zusammenfassung:	CD44 is a common leukocyte adhesion molecule expressed on the surface of various cells. Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. The binding of small molecular mass HA (SMM-HA, MW
ISSN:	0360-3997 1573-2576
DOI:	10.1007/s10753-017-0622-5