Sleep abnormalities in juvenile myoclonic epilepsy—A sleep questionnaire and polysomnography based study

•Poor sleep quality in patients of JME irrespective of their treatment status.•Sleep architecture is disrupted with decreased duration of REM and increased NREM1.•Epileptiform discharges are frequent in lighter NREM sleep.•AEDs disrupt the NREM sleep however, lowers the epileptiform discharge index.•Perhaps GABA receptor dysfunction contributes both for epilepsy and decreased REM. To evaluate the quality of sleep, its architecture and occurrence of epileptiform discharges with their distribution across various stages of sleep in patients of Juvenile myoclonic epilepsy (JME), both drug naïve as well as those already on treatment. 99 patients of JME [36 drug naïve, 63 on antiepileptic drug(s) (AED)], and 30 healthy controls were recruited. Sleep quality and daytime sleepiness were evaluated with Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), respectively.Polysomnography (PSG) was done to assess the sleep architecture. The EDI (Epileptiform Discharge Index) per stage of sleep was calculated. JME patients had significantly poor quality of sleep by PSQI (p=0.02).PSG revealed reduced sleep efficiency [p