Cysteine-Containing Peptides Stimulate Monocyte Migration through NADPH-Oxidase Activation

Cysteine-Containing Peptides Stimulate Monocyte Migration through NADPH-Oxidase Activation

We analyzed migration of monocytes under the effect of apocinin (NADPH inhibitor) and PD98059 (blocker of extracellular MEK/ERK kinase involved in Nox4 oxidase-mediated migration of monocytes). Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bulletin of experimental biology and medicine 2017-06, Vol.163 (2), p.203-205
Hauptverfasser: Krasnikova, T. L., Arefieva, T. I., Pylaeva, E. A., Sidorova, M. V.
Format: Artikel
Sprache:eng
Schlagworte:
Active oxygen
Atherosclerosis
Biomedical and Life Sciences
Biomedicine
Cell activation
Cell Biology
Cell Movement - drug effects
Cells, Cultured
Chemokine CCL2 - pharmacology
Chemokine CX3CL1 - pharmacology
Chemokines
Cysteine
Cysteine - chemistry
Cystine
Extracellular signal-regulated kinase
Fractalkine
Humans
Internal Medicine
Laboratory Medicine
Leukocyte migration
Macrophages
MAP Kinase Signaling System - drug effects
Monocyte chemoattractant protein 1
Monocytes
Monocytes - drug effects
Monocytes - metabolism
NAD(P)H oxidase
NADP - metabolism
NADPH Oxidases - metabolism
NOX4 protein
Oxidases
Pathology
Peptides
Peptides - chemistry
Peptides - pharmacology
Reactive Oxygen Species - metabolism
Thiols
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We analyzed migration of monocytes under the effect of apocinin (NADPH inhibitor) and PD98059 (blocker of extracellular MEK/ERK kinase involved in Nox4 oxidase-mediated migration of monocytes). Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker. It is assumed that the stimulating effect of cysteine-containing peptides on monocyte migration is mediated by the NADPH-oxidase system, in particular, Nox4.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3766-2