Differential involvement of spinal protein kinase C and protein kinase A in neuropathic and inflammatory pain in mice

In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent c...

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Veröffentlicht in:	Brain research 2003-12, Vol.992 (2), p.288-293
Hauptverfasser:	Yajima, Yoshinori, Narita, Minoru, Shimamura, Masahiro, Narita, Michiko, Kubota, Chiharu, Suzuki, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology Hyperalgesia - chemically induced Hyperalgesia - enzymology Hyperalgesia - physiopathology Immunohistochemistry Inflammation - enzymology Inflammation - physiopathology Inflammation Mediators - pharmacology Inflammatory pain Male Medical sciences Mice Mice, Inbred ICR Nervous system (semeiology, syndromes) Neuralgia - enzymology Neuralgia - physiopathology Neurology Neuropathic pain Pain Threshold - drug effects Pain Threshold - physiology Peripheral Nervous System Diseases - enzymology Peripheral Nervous System Diseases - physiopathology Posterior Horn Cells - cytology Posterior Horn Cells - enzymology Protein kinase A Protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Reaction Time - drug effects Reaction Time - physiology Sciatic Neuropathy - enzymology Sciatic Neuropathy - physiopathology Spinal cord Spinal Cord - cytology Spinal Cord - enzymology Up-Regulation - drug effects Up-Regulation - physiology
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Beschreibung
Zusammenfassung:	In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent caused a protein kinase A (PKA)-related thermal hyperalgesia. These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2003.08.042