Inter- and Intrafractional Variation in the 3-Dimensional Positions of Pancreatic Tumors Due to Respiration Under Real-Time Monitoring

To quantify the 3-dimensional pancreatic tumor motion during the overall treatment course using real-time orthogonal kilovoltage X-ray imaging. This study included 10 patients with pancreatic cancer who underwent 6-port static intensity modulated radiation therapy with real-time tumor tracking in 15...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 2017-08, Vol.98 (5), p.1204-1211
Hauptverfasser: Akimoto, Mami, Nakamura, Mitsuhiro, Nakamura, Akira, Mukumoto, Nobutaka, Kishi, Takashi, Goto, Yoko, Mizowaki, Takashi, Hiraoka, Masahiro
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Sprache:eng
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Zusammenfassung:To quantify the 3-dimensional pancreatic tumor motion during the overall treatment course using real-time orthogonal kilovoltage X-ray imaging. This study included 10 patients with pancreatic cancer who underwent 6-port static intensity modulated radiation therapy with real-time tumor tracking in 15 fractions, except for 1 patient (5 fractions). The tumor and abdominal wall positions were acquired simultaneously during the overall treatment course. Then the tumor motion amplitude and reference positions were determined. The mean tumor amplitudes were 4.9, 6.5, and 13.4 mm in the left–right (LR), anterior–posterior (AP), and superior–inferior (SI) directions, respectively. The intrafractional variations of the reference tumor position were up to 5.4, 10.2, and 10.7 mm in the LR, AP, and SI directions, and those of the reference abdominal position were up to 10.5 mm. The reference tumor position drifted significantly in the AP and SI directions after 10 minutes, and that of abdominal wall motion drifted during the first 15 minutes (P
ISSN:0360-3016
1879-355X
DOI:10.1016/j.ijrobp.2017.03.042