Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells

CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizin...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2017-08, Vol.53 (62), p.8671-8674
Hauptverfasser:	Zhou, Yiqing, Di, Zhengao, Li, Xiaoming, Shan, Yuanhong, Li, Weichao, Zhang, Haibing, Xiao, Youli
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic Agents - pharmacology Basigin - genetics Basigin - metabolism Cysteine-Rich Protein 61 - genetics Cysteine-Rich Protein 61 - metabolism Diterpenes - pharmacology Gene Knockdown Techniques HeLa Cells Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 7 - metabolism Matrix Metalloproteinase 9 - metabolism Photoaffinity Labels - pharmacology Proteomics Swine Tubulin - metabolism
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Beschreibung
Zusammenfassung:	CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c7cc04345g