Optic neuritis in pregnancy after Tdap vaccination: Report of two cases

•Tdap vaccination in pregnancy has been demonstrated to be the most effective strategy for preventing pertussis in newborns.•Neurological inflammatory disorders have been described previously associated with the administration of various vaccines.•There are no neurologic complications related with Tdap vaccine until the moment.•Two cases of optic neuritis in pregnant following this vaccine are present.•Relationship between vaccination and ON causation is suggested. Two pregnant women developed one-eye blurring vision within three weeks after Tdap vaccination. Neurophtalmologic and MR examination confirmed an unilateral optic neuritis without evidence of underlying disease. Both patients had a full recovery, one after intravenous metilprednisolone. This is the first report of optic neuritis related with Tdap vaccination in pregnancy.