The role of clotting factor IX in the development of atherosclerosis

Highlights • The severe deficiency of FIX did not protect the animals from the development of atherosclerotic plaques in the aortic areas evaluated after periods of 8 and 22 weeks. • In the qualitative evaluation related to smooth muscle (a-actin), and macrophages did not differ between the control...

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Veröffentlicht in:	Thrombosis research 2017-09, Vol.157, p.79-81
Hauptverfasser:	de Paula, Laís Ívina Ívina Silva, Urban, Aline, Costa, Devanira Souza Paixão, de Paula, Erich V, Annichino-Bizzacchi, Joyce M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - blood Factor IX - metabolism Hematology, Oncology and Palliative Medicine Mice Mice, Knockout
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description	Highlights • The severe deficiency of FIX did not protect the animals from the development of atherosclerotic plaques in the aortic areas evaluated after periods of 8 and 22 weeks. • In the qualitative evaluation related to smooth muscle (a-actin), and macrophages did not differ between the control and experimental groups. • With the improvements in treatment for haemophilia and prolonged survival and life expectancy, atherosclerosis and cardiovascular disease would certainly be on the rise in these patients.
doi_str_mv	10.1016/j.thromres.2017.04.025
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subjects	Animals Atherosclerosis - blood Factor IX - metabolism Hematology, Oncology and Palliative Medicine Mice Mice, Knockout
title	The role of clotting factor IX in the development of atherosclerosis
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